Spotting Spondyloarthropathy: Recognizing Signs Beyond Back Pain

  • 											Array
        [name] => A/Prof Leong Keng Hong
        [avatar] => https://thisquarterly.sg/wp-content/uploads/2018/12/Prof-Leong-Keng-Hong.jpg
        [tiny_avatar] => https://thisquarterly.sg/wp-content/uploads/2018/12/Prof-Leong-Keng-Hong-tiny.jpg
        [address] => Leong Keng Hong Arthritis and Medical Clinic
    6 Napier Road
    #04-18 Gleneagles Medical Centre
    Singapore 258499
    Tel: 6472 4337
        [id] => 2099
        [doctor_link] => https://thisquarterly.sg/doctors-panel/rheumatologist/a-prof-leong-keng-hong/
        [specialization] => Rheumatologist
        [specialization_id] => 38
        [specialization_link] => https://thisquarterly.sg/doctors_panel/rheumatologist/
  • December 6, 2023
  • 2 minutes read

Chronic pain in the lower back can be more significant than you realise. Learn about spondyloarthropathy and how to spot the signs.

Spondyloarthropathy causes back pain, joint pain and inflammation, and can be mistaken for other types of pain. This is because awareness of this autoimmune disease tends to be low. And because the condition affects younger people, many downplay and manage the symptoms until the condition worsens.

In spondyloarthropathy, the immune system gets confused and attacks the body. The term refers to a family of long-term diseases of the joints that include ankylosing spondylitis, Reiter’s syndrome (reactive arthritis), psoriatic arthritis, and joint problems linked to inflammatory bowel disease (enteropathic arthritis). While each of these specific conditions present different symptoms and outcomes, they are similar in that all of them:

  • usually involve the sacroiliac joint in the lower back, causing pain in the buttocks area
  • affect areas where your ligaments and tendons attach to bone, most commonly causing pain in the heel
  • involve stiffness in the back or neck that is worse in the morning and after periods of rest but gets better during the day and after exercise
  • cause fatigue

Types of Spondyloarthropathles

Ankylosing Spondylitis causes stiffness and lower back pain. In severe cases, the affected joints in the spine fuse together. In children, the signs start in the hips, knees, heels or big toes, and progress to the spine. Other areas such as the chest wall and heels may also be affected.

Reiter’s Syndrome causes pain, swelling and inflammation of the joints after infections, especially sexually transmitted diseases. The fingers and toes may swell, and fever, weight loss, skin rash, mouth ulcers and inflammation of the eyes can also occur.

Psoriatic Arthritis is a type of arthritis associated with psoriasis (scaly red patches on the skin). This rash precedes the arthritis symptoms, sometimes by years. Fingernails and toenails may also become thickened and yellow. Psoriatic arthritis involves both small and large joints, such as the fingers, toes, knees, hips and sacroiliac joints (tailbone).

Enteropathic Arthritis is spinal arthritis that also involves inflammation of the intestinal wall. The arthritis affects large joints such as the knees, hips, ankles, and elbows.


Short-term medicine includes painkillers to reduce swelling and pain. It is more important to consider disease-modifying medication which controls the immune system, such as sulfasalazine and methotrexate. In recent times, research has shown a role for the newer biologic disease-modifying drugs such as anti-tumour necrosis factor agents that are now approved for use in several countries. They have been shown to be highly effective in treating not only arthritis of the joints but spinal arthritis associated with ankylosing spondylitis and related diseases. This class of drug attempts to block a protein that causes inflammation.

Spondyloarthropathy or Rheumatoid Arthritis?

While both cause joint pain and swelling, the pattern of joints affected is different. Spondyloarthropathy also has a different diagnostic marker. It is associated with the presence of the HLA-827 gene, while rheumatoid arthritis is linked to a different marker. Spondyloarthropathy tends to affect more men, while rheumatoid arthritis affects more women.

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